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Tolfine-Tolfedine CS

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Dairy
Tolfine-Tolfedine CS

The only NSAID registred as a single injection in the management of bovine mastitis

 Composition

Injectable solution :
Tolfenamic acid…………………………4.00 g
Sodium hydroxymethanesulfinate….…0.50 g
Benzyl alcohol…………………………1.04 g
Excipient to…………………………….100 ml

 Properties

Tolfenamic acid is a non-steroidal anti-inflammatory of the fenamate family. It inhibits prostaglandin synthesis and also inhibits the tissue response to prostaglandins which is not the case of the non-steroidal anti-inflammatories. Its action is antipyretic, analgesic and anti-inflammatory.
Tolfenamic acid follows an entero-hepatic cycle, ensuring a long half-life time, permitting administrations more spaced out than with other anti-inflammatories, especially by the intramuscular route where the activity is maintained for 48 hours (intravenous route : 24 hours).
Tolfine® has a low toxicity and is well tolerated : no side effects were noted during clinical trials.
Local reactions are very rare and have never appeared during injections in the neck (presence of aponeurosis and numerous intramuscular spaces).

 Indications

In cattle : non-steroidal anti-inflammatory.

 Administration and dosage

Cattle :
• Intramuscular route : a single injection of 1 ml per 20 kg of b.w., to repeat every 48 hours.
• Intravenous route: a single injection of 1 ml per 20 kg of b.w., to repeat every 24 hours, or to relay 24 hours later with intramuscular injections.
Do not exceed 5 consecutive injections.

 Withdrawal period

Meat and offal : 12 days.
Milk : zero days.

 Category

List II.
Prescription only medicine that should be preserved for duration of the withdrawal period of the drug.

 Presentation

50 ml vial
M.A. N°687 466.8 of the 14/04/89
100 ml vial
M.A. N°687 417.7 of the 14/04/89
250 ml vial
M.A. N°687 430.3 of the 14/04/89

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