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Octacillin

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Poultry

OCTACILLIN water soluble powder for chickens 697 mg/g

The data on withdrawals, target species and dosages can be different in your country, please check your national registration of the product.

Target species 
Chickens (excluding laying birds producing eggs for human consumption).

Composition 
Active substance:
Amoxicillin (as Amoxicillin trihydrate Ph. Eur.) 697 mg/g

Pharmaceutical form 
Powder for oral solution.

Indications for use
Treatment of infections in chickens caused by bacteria susceptible to amoxicillin.
Not effective against beta-lactamase producing organisms.

Contraindications
Do not use in known cases of hypersensitivity to penicillin or other substances of the beta-lactam group.
Do not use in rabbits, guinea pigs, hamsters, gerbils or any other small herbivores.

Amounts to be administered and administration route
The recommended dosage is 10-20 mg/kg live weight OCTACILLIN powder (8-16 mg/kg amoxicillin trihydrate) per day administered in the drinking water. The higher dose is advised when treating severe infections. Treatment should be given for a period of 3-5 consecutive days. The following formula may be used to calculate the amount of OCTACILLIN required per day:

 gram OCTACILLIN per day =  number of birds x average live weight (kg)
 50 (for 20 mg/kg) or 100 (for 10 mg/kg)

If the required amount of OCTACILLIN is calculated by the total daily water intake, the following is a guide:
• Birds 0-4 weeks of age: 6-12 g OCTACILLIN / 100 litres water uptake/day
• Birds older than 4 weeks: 10-20 g OCTACILLIN / 100 litres water uptake/day
It is recommended that OCTACILLIN be administered once daily in the drinking water. It is advisable to restrict drinking water for approximately 2 hours (less in hot weather) prior to medication. The use of suitably calibrated weighing equipment for the administration of the calculated amount of OCTACILLIN is recommended. The calculated total daily amount of powder is scattered onto the surface of 5-10 litres of clean water and stirred until evenly dispersed. This solution is then added, whilst stirring, into an amount of drinking water that will be consumed within approximately 2 hours. Maximum solubility of OCTACILLIN in water is approximately 6 g/litre.
If, however, continuous medication is preferred then the drinking water should be refreshed with medicated water at least twice daily. In all cases ensure that there is no access to unmedicated water whilst medicated water is being offered. When all medicated water has been consumed, turn on the normal water supply again. Any unused medicated water should be discarded after 12 hours.
To ensure a correct dosage body weight should be determined as accurately as possible to avoid underdosing. The uptake of medicated water depends on the clinical condition of the animals. In order to obtain the correct dosage the concentration of amoxicillin has to be adjusted accordingly.

Special precautions to be taken by the person administering the veterinary medicinal product to animals 
Penicillins and cephalosporins may cause hypersensitivity (allergy) following injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may cause cross reactions to cephalosporins and vice versa. Allergic reactions to these substances may occasionally be serious.
1. People with known hypersensitivity to penicillin or cephalosporin should avoid contact with the product.
2. Handle this product with great care to avoid exposure, taking all recommended precautions. Wear protective clothing, impervious gloves and either a disposable half mask respirator conforming to European Standard EN149 or a non-disposable respirator conforming to European Standard EN140 with a filter to EN 143 when mixing and handling the product. Wash hands immediately after handling the product.
3. If you develop symptoms following exposure, such as a skin rash, you should seek medical advice and show the doctor this warning. Swelling of the face, lips or eyes or difficulty with breathing are more serious symptoms and require urgent medical attention.

Special precautions for use in animals
Not applicable.

Adverse reactions (frequency and seriousness)
Hypersensitivity reactions may occur.

Use during pregnancy or lactation
Do not use in birds in lay producing eggs for human consumption. Use in breeders only according to the benefit / risk assessment by the responsible veterinarian

Interactions with other veterinary medicinal products and other forms of interaction 
Amoxicillin exerts its bactericidal action by inhibition of bacterial cell wall synthesis during multiplication. It is therefore in principle not compatible with bacteriostatic antibiotics (e.g. tetracyclines) which inhibit multiplication. Synergism occurs with ß-lactam antibiotics and aminoglycosides.

Overdose (symptoms, emergency procedures, antidotes) if necessary
None known.

Withdrawal periods
Meat: 24 hours
Eggs: Not permitted for use in laying birds producing eggs for human consumption

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